Papers
Invited Papers and Presentations
1. A. Adjei, "Pulmonary Delivery of Leuprolide Acetate", Invited Lecture to
the Graduate School, College of Pharmacy, The University of Texas at Austin,
February 8, 1990.
2. A. Adjei, "Pulmonary Delivery of Peptide Drugs: Animal Models,
Preclinical Studies, and Clinical Results", Respiratory Drug Delivery II,
Brackenridge, Colorado, March 22-26, 1990.
3. A. Adjei, "Nasal Delivery Of Peptide Drugs: Case Studies with Leuprolide
Acetate", Nasal And Inhalation Drug Delivery Symposium, Princeton, New
Jersey, April, 1990.
4. A. Adjei, "Justification of Laser Light Scattering Method (Malvern Series
2600c) for Size Analysis in Inhalation Aerosols", AAPS Aerosol Sub-committee
Meeting, SmithKline Beecham, King of Prussia, New Jersey, Sept. 11, 1990.
5. L. Adjei, D. Lee, and T. Reiland, "Light Scattering Method for Sizing
Pharmaceutical Aerosols: Correlation with Impaction Methods", Regulatory
Issues in Aerosol Drug Development, University of Kentucky Department of
Continuing Education, Crystal City, New Jersey, June 12-14, 1991.
6. A. Adjei, "Nasal Absorption of LH-RH Analogs: A Case Study With The
Nonapeptide Leuprolide Acetate", Department of Pharmacy, University of
California San Francisco, Feb. 26, 1992.
7. A. Adjei and M. FuLu, "Formulations of LH-RH Analogs for the Palliative
Treatment of Endometriosis", Midwest Regional Chapter, American Association
of Pharmaceutical Research, Chicago, Marriott-O'Hare, Illinois, May 4, 1992.
8. A. L. Adjei and P. J. Carrigan, "Pulmonary Bioavailability of LH-RH
Analogs: Some Biopharmaceutical Guidelines", Respiratory Drug Delivery III,
Williamsburg, Virginia, May 16-22, 1992 [Also in J. Biopharm. Sci., 3(1/2),
247-254, 1992].
9. A. L. Adjei , "Pulmonary Bioavailability of Peptide Drugs: A Case Study
with Leuprolide and other LH-RH Analogs", Chelsea College of Pharmacy, The
University of London, London, June 8, 1992 [Also presented by special invite
at Advances in Delivery of Therapeutic And Diagnostic Agents, Control
Release Society Meeting, December 9-11, 1992, Sydney, Australia; and also at
International Symposium of Aerosols in Medicine, Garmisch-Partenkirchen,
Germany, March 30-April 3, 1993].
10. A. V. Annapragada, A. L. Adjei, T. J. Hale, "A Review of The
Capabilities And Limitations of The Fraunhoffer Diffraction Pattern Analysis
Method of Particle Size Distribution Analysis", First International
Conference on Pharmaceutical Sciences And Technology, 24th Annual Meeting of
The Fine Particle Society, Chicago, IL. August 24-28, 1993.
11. P. K. Gupta, M. FuLu, L. Adjei, "Application of Biodegradable
Microspheres in Drug Delivery", First International Conference on
Pharmaceutical Sciences And Technology, 24th Annual Meeting of The Fine
Particle Society, Chicago, IL. August 24-28, 1993.
12. A. Adjei, "Pharmaceutical Aerosols, Past, Present, and Future:
Perspectives on Peptide and Protein Drug Delivery", Chicagoland
Pharmaceutical Discussion Group, Chicago College of Pharmacy, May 19, 1994.
13. P. Gupta, A. Adjei, "Recent Developments in Inhalation Drug Delivery",
46th Indian Pharmaceutical Congress" Meeting, Dec. 19-21, 1994, Chandigash,
India.
14. A. Adjei, “Regulatory Issues Concerning Systemic Delivery Via The
Respiratory Tract: Leuprolide as a Demonstration Model”, International
Symposium on Aerosols in Medicine, May 15-19, 1995, Hamilton, Ontario,
Canada.
15. A. Adjei, "Absorption and Retention of Pharmaceutical Particles from the
Lung: Perspectives on Peptide and Protein Drug Delivery", Midwest Regional
Chapter, American Association of Pharmaceutical Scientists, Annual Meeting,
Chicago, Marriott-O'Hare, Illinois, May 22, 1995.
16. A. Adjei, “"Pulmonary Delivery of Therapeutic Peptide and Proteins:
Pharmaceutical Perspectives ", Fine Particle Society Annual Meeting,
Marriott-O'Hare, Illinois, August 21-25, 1995.
17. A. Adjei, “Pulmonary Drug Delivery: The Future is Now”, American
Institute of Chemical Engineers (AIChE) Annual Meeting, Miami, Nov. 12-17,
1995.
18. A. Adjei, “Inhaled Peptides and Proteins for Systemic Diseases’ Advances
in Inhalation Therapy, The National Heart and Lung Institute, Brompton
Hospital, The Imperial College, University of London, February 21-23, 1996,
England.
19. A. Adjei, “Systemic Delivery of LH-RH Analogs via Various Routes of
Administration”, Impact of Administration Routes On Effective Drug Delivery,
PDD Section, American Association of Pharmaceutical Scientists, Annual
Meeting, Seatle, Washington, October 27-31, 1996.
20. P. Gupta and A. Adjei, “Inhaled Peptides and Proteins for Systemic
Diseases’ Biomedical Engineering Society 1996 Annual Fall Meeting,
Pennsylvania State University, University Park, Pennsylvania, October 3-6,
1996.
21. A. Annapragada, A. Adjei, F. Muzzio and P. Swanson, “Simulation of
Particle Deposition in Geometries Relevant to Inhalation Aerosol Drug
Delivery” Biomedical Engineering Society 1996 Annual Fall Meeting,
Pennsylvania State University, University Park, Pennsylvania, October 3-6,
1996.
22. “Pulmonary Absorption of LH-RH Analogs”, A. L. Adjei, The Impact of
Routes of Administration on Effective Drug Delivery, Annual AAPS meeting,
Seatle, WA, Oct. 27-31, 1996.
23. A. Adjei, “Systemic Delivery of Macromolecular Drugs: Case Study with
GnRH Analogs, Workshop on Lungs, Drugs and Devices, Swedish Academy of
Pharmaceutical Sciences Annual Meeting, Stockholm, November 11-13, 1996,
Sweden.
24. A. Adjei, J. Sun, F. Zhang, “Use of the Light Scattering Method (Malvern
Model 2600c) for Sizing Pharmaceutical Aerosols: Correlation with Impaction
Methods”, 5th International Congress on Optical Particle Sizing”,
Minneapolis, MN, August 10-14, 1998.
25. A. Adjei, “Safety of an Inhaled LH-RH Agonist in Animals and Humans”,
Immunological and Biological Aspects of Therapeutic Protein Delivery to the
Lungs, Keystone Symposia, March 3-8, 1999, Durango, Colorado.
26. A. Adjei, “Systemic Delivery of Biotherapeutics via Lung Kinetics and
Modulation of Uptake”, Management Forum, October 10-11, 2000, London.
27. A. Adjei, “Non-CFC Aerosol Formulation Science: New Technologies, Patent
Landscape, and Proprietary Considerations”, Inhalation Technology Workshop,
Annual AAPS Meeting, Indianapolis, October 28, 2000.
28. A. Adjei and A. Annapragada, “Theoretical and Practical Approaches to
Formulation for Systemic Delivery”, Management Forum, October 4-5, 2001,
London.
Contributed Papers at Conferences Published by Abstract
1. A. Adjei, J. Newburger, S. Stavchansky and A. Martin, "Solubility of
Theophylline: Effect of Solvent Properties on In Situ Drug Release",
Presented at the Academy of Pharmaceutical Sciences National Meeting,
Hollywood, Florida, November 1978.
2. A. Adjei, J. Newburger and A. Martin, "Extended Solubility Approach III;
Predictions of Caffeine Solubility in Dioxane-Water Mixtures", Presented at
the APhA and Academy of Pharmaceutical Sciences Meeting, Washington D.C.,
March, 1980.
3. L. Sanathanan, T. Lin, L. Hsu and A. Adjei, "Shelf-Life Assessment of the
Pharmaceuticals from Multi-stage Stability", Presented at the Annual
American Pharmaceutical Association Meeting, Montreal, Canada, May, 1984.
4. A. Adjei, J. Bauer, K. Marsh, D. Mendenhall, "The Development of the
Orphan Drug, Panhematin", Presented at the Annual American Pharmaceutical
Association Meeting, Montreal, Canada, May, 1984.
5. A. Adjei, E. Johnson, R. Doyle, K. Sims, "Formulation Development of A
Nonapeptide: In-Vitro and In-Vivo Studies", Japanese-United States Congress
of Pharmaceutical Sciences, Honolulu, Hawaii, December 1987 [Also published
in J. Pharm. Sci., 76(11): PS47, 1987].
6. A. Adjei, G. Menon, R. Doyle "Effect of Ion-Pairing on Octanol-Water
Partitioning of the Nonapeptide Leuprolide Acetate", Presented at the
Biotechnology Session, Western Regional Chapter, AAPS, Reno, Nevada, January
31 - February 6, 1988.
7. A. Adjei, E. Johnson, G. Menon, R. Finley, L. Sennello "Effect of
Lipophilicity on Nasal Bioavailability of Peptide Drugs", Presented at the
Annual American Association of Pharmaceutical Scientists Meeting, Orlando,
Florida, October 1988.
8. G.J. Diaz, E.N. Bush, A.T. Nguyen, H. Nellans, E.S. Johnson, S.K. Love,
A. Adjei, J. Greer, F. Haviv, "Development Strategy For Novel LHRH Analogs
Based on Pharmacokinetics And In Vitro Potency", Midwest Regional Meeting,
American Association of Pharmaceutical Scientists, Chicago, May 15, 1989
9. M. Vadnere, A. Adjei, and R. Doyle, "Evaluation of Alternate Routes for
Delivery of Leuprolide", Disposition and Delivery of Peptide Drugs - FIP
Satellite Symposium, Leiden, The Netherlands, Sept. 1-3, 1989.
10. A. Adjei, M. Vadnere, G. Menon, J. Garren, P. Moy, S. Rao, "Effect of
Ion-Pairing of A Nonapeptide Leuprolide Acetate", American Association of
Pharmaceutical Sciences Annual Meeting, Atlanta, Georgia, October 22-26,
1989 [Also in Also in Pharm. Res. 6(Suppl 9):S-121, Sept. 1989].
11. A. Adjei, R. Doyle, J. Garren, M. Vadnere, P. Moy, A. Chun,
"Micromeritics of Leuprolide Acetate: Correlation with Pulmonary
Bioavailability", American Association of Pharmaceutical Sciences Annual
Meeting, Atlanta, Georgia, October 22-26, 1989; [Also published in Pharm.
Res. 6(Suppl 9):S-152, Sept. 1989].
12. A. Adjei, D. Sundberg, J. Miller, M. Vadnere, "Bioavailability of
Leuprolide Acetate Following Nasal Delivery to Healthy Humans", [American
Association of Pharmaceutical Sciences Annual Meeting, Las Vegas, November
4-9, 1990].
13. J. Garren, K. Marsh, A. Adjei "Pulmonary Delivery of a Poorly Orally
Absorbed Renin Inhibitor", Pharmaceutical Research 7(Suppl 9):S-134, Sept.
1990, Abstract PDD 7089 (American Association of Pharmaceutical Sciences
Annual Meeting, Las Vegas, November 4-9, 1990).
14. Y. Qiu, P. Gupta, H. Cheskin, A. Adjei "Pulmonary Bioavailability and
Absorption Characteristics of the 5-Lipoxygenase inhibitor, Abbott-79175, in
Beagle Dogs” Pharmaceutical Research, 11: s-207, 1994. [Presented at the
Annual AAPS meeting, Los Angeles, CA., Nov. 6-10, 1994].
15. “Pulmonary Absorption of a 5-Lipoxygenase Inhibitor, Abt-761, Following
Intratracheal and Aerosol Delivery to Beagle Dogs”, P. Gupta, Y. Qiu, C.
Allexon, V. Wu and L. Adjei, Pharmaceutical Research, s-168. [Presented at
the Annual AAPS meeting, Seatle, WA, Oct. 27-31, 1996].
16. “Enzymatic Degradation of A-43818 in Rat Intestinal Mucosa”, Y. Zheng,
M. FuLu, H. Johnson, L. Adjei and T. Reiland, Pharmaceutical Research,
13(9):S-401. [Presented at the Annual AAPS meeting, Seatle, WA, Oct. 27-31,
1996].
17. “Aerosol Delivery of the 5-Lipoxygenase Inhibitor, A-85761, in Dogs” P.
Gupta, Y. Zheng, Y. Qiu and A. Adjei, [Presented At the 11th Biennial
International Society for Aerosols in Medicine September 23-26, 1997,
Sendei, Japan].
18. “Aerosol Delivery of the 5-Lipoxygenase Inhibitor, A-79175, in Dogs” A.
Adjei, Y. Zheng, Y. Qiu and P. Gupta, [Presented At the 11th Biennial
International Society for Aerosols in Medicine September 23-26, 1997,
Sendei, Japan].
19. “Evaluation of the AERxÔ Pulmonary Delivery System for Systemic Delivery
of a Selective D1 Agonist”, F. W. Okumu, R-Y Lee, J. D. Balanchard, D.
Cipolla, C. M. Woods, P. M. Lloyed, J. Okigawa, I. Gonda, S. J. Farrr, R.
Rubsamem, A. L. Adjei, R.J. Bertz . [American Association of Pharmaceutical
Sciences Annual Meeting, San Francisco, PDD-2714, November 14-19, 1998].
20. “Pulmonary Delivery of ABT-431”, Y. Zheng, L. Adjei, P. K. Gupta and H.
Cheskin [Presented at the Nasal And Pulmonary Drug Delivery Symposium,
American Association of Pharmaceutical Sciences Annual Meeting, San
Francisco, PDD-2261, November 14-19, 1998].
21. “A Reproducible, Sensitive, Single Spray Quantitation Method for
Triamcinolone Acetonide Pressurized Metered Dose Inhaler (pMDI) Using the
Breath Coordinated Inhaler (BCI)”, James F. Tanguay, John Z. Sun, Akwete L.
Adjei [Presented at the Respiratory Drug Delivery (RDD7) Symposium, Tarpon
Springs, May 14-18, 2000].
22. The Breath Coordinated Inhaler (BCI): A New Pulmonary Drug Delivery
Device For Pressurized Metered Dose Inhalers, F. Zhang, P. Genova*, J.
Tanguay, J. Cronin, F. Sexton, A. Cutie, W. Jewett, A. L. Adjei [Presented
at the Respiratory Drug Delivery (RDD7) Symposium, Tarpon Springs, May
14-18, 2000].
23. A New, Stable, Improved pMDI Formulation of Triamcinolone Acetonide
(TAA) as an Alternative to the Commercial Comparator, John Z. Sun, James F.
Tanguay, Anthony J. Cutie, & Akwete L. Adjei [Presented at the Respiratory
Drug Delivery (RDD7) Symposium, Tarpon Springs, May 14-18, 2000].
24. New Developments in Macromolecular Drug Delivery Using the pMDI, Yaping
Zhu, Simon Stefanos, P. Genova, Akwete L. Adjei [Presented at the
Respiratory Drug Delivery (RDD8) Symposium, Tucson, Arizona, May 12-17,
2002].
25. Time-Action Profile of a New Pulmonary Insulin Applied with a
Metered-Dose Inhaler, Amy Buchwald, Mark McGovern, Eugenio A. Cefali, Lex
Adjei, Perry Genova, Christoph Kapitza, Tim Heise, Lutz Heinemann, Marcus
Hompesch, [Presented at the 4th Conference of Retrometabolic Drug Design
Symposium, Palm Coast, Florida, May 11-14, 2003]
26. Time-Action Profile of a new Pulmonary Insulin Applied with a
Metered-Dose Inhaler. Amy Buchwald PhD, Mark McGovern MD, Eugenio A. Cefali
PhD, Lex Adjei PhD, Perry Genova PhD, Christoph Kapitza MD, Tim Heise MD,
Lutz Heinemann PhD and Marcus Hompesch MD. [Practical Approaches to Nasal
and Pulmonary Drug Delivery II, February 9-11, 2004 Delray Beach (FL-USA)].
27. PULMONARY DELIVERY OF INSULIN USING THE ASTHMA PLATFORM MODEL Perry
Genova PhD, Amy Buchwald PhD, Mark McGovern MD, Eugenio A. Cefali PhD, Lex
Adjei PhD, Christoph Kapitza MD, Tim Heise MD, Lutz Heinemann PhD, Marcus
Hompesch MD, Diabetic Technology, San Francisco, November 3-4, 2003
28. Pulmonary Delivery of Insulin using the Asthma Platform Model, Perry
Genova PhD1, Amy Buchwald PhD2, Mark McGovern MD2, Eugenio A. Cefali PhD2,
Lex Adjei PhD2, Christoph Kapitza MD3, Tim Heise MD3, Lutz Heinemann PhD3
and Marcus Hompesch MD3 [Respiratory Drug Delivery IX in Palm Desert,
California, April 25-29, 2004]
29. An investigation of the solubility of recombinant human insulin in
tetrafluoroethane propellant and aqueous media, Inayet Dumanli, Ph.D.,
Dominick Larosa, Yaping Zhu, Ph.D., and Akwete Adjei, Ph.D. [Respiratory
Drug Delivery IX in Palm Desert, California, April 25-29, 2004]
30. A Simple Analytical Model to Estimate the Impact of Propellant
Evaporation on the Change of Formulation Concentration in a pMDI Canister or
in a Batch Manufacturing Formulation Tank, Lei (Frank) Zhang, Ph.D.
(Schering-Plough Research Institute) and Akwete L. Adjei, Ph.D. (Kos
Pharmaceuticals) [Respiratory Drug Delivery IX in Palm Desert, California,
April 25-29, 2004]
31. Kos Inhaled Insulin Dosed with a Metered Dose Inhaler as Efficacious as
Lantus® In Poorly Controlled Type 2 Diabetic Patients with Sulfonylureas or
Metformin; Amy Buchwald, Lex Adjei*, Phil Simmons*, Michaela Hausmann*,
Sibylle Dellweg*, Tim Heise*, and Lutz Heinemann*. Kos Pharmaceuticals,
Inc., USA and Profil Institut Für Stoffwechselforschung GmbH, Germany [34th
Annual Meeting of the American College Clinical Pharmacology, Doubletree
Hotel in Rockville, Maryland, September, 11-13, 2005]
32. A modulated DSC study on recombinant human insulin in solid-state,
Inayet Dumanli, Yaping Zhu, and Lex Adjei [American Association of
Pharmaceutical Sciences, Annual Meetng, Memphis, Nov. 3-8th, 2005]
33. Characterization of recombinant human insulin using capillary
electrophoresis, Xiaofeng Meng, Yaping Zhu, Simon Stefanos and Lex Adjei,
[American Association of Pharmaceutical Sciences, Annual Meeting, Memphis,
Nov. 3-8th, 2005]
34. Need for Better Alignment between OINDP Capabilities and FDA DDU
Requirements; Lex Adjei; David Cipolla; Clarie D’Abrue-Hayling; Sarvajna
Dwivedi; Kristi Griffiths; Niels Hartvig; Colin Hunter; Michael Golden;
Douglas Lee; Stefan Leiner; Stefan Mueller; Svetlana Lyapustina; Bo Olsson;
Dennis Sandell and Bruce Wyka. Submitted to ISAM Journal, January 22, 2006.
35. Characterization of Automated Wasting Station Parameters Influencing
Through-Life Dosing Uniformity Performance of a pMDI, Kou Vang, Lynn Krebs,
Christopher M. Shelton, Steven Pilewski, Sam Shum, Lex Adjei [Respiratory
Drug Delivery X, Boca Raton Resort and Club, Boca Raton, Florida, April
23-27, 2006]
36. Determination of Extractable Formaldehyde in Metered-dose Packaging
Components by HPLC-MS", Anulfo Valdez, Frances Amegayibor, Stephen Ampofo,
Yaping Zhu and Lex Adjei; Poster presentation at the 54th Annual American
Society for Mass Spectrometery (ASMS) Conference in Seattle, WA (May 28th -
June 1, 2006) |
